Circadian variation in haematological toxicity of the immunosuppressive agent "Mycophenolate Mofetil" in rats
نویسندگان
چکیده
منابع مشابه
Circadian variation in haematological toxicity of the immunosuppressive agent “Mycophenolate Mofetil” in rats
Because of biological rhythms, drug efficiency and toxicity vary according to the time of administration of the drug. This study investigates whether the haematological toxicity of the immunosuppressive agent Mycophenolate Mofetil varies according to the circadian dosing-time in rats. 300 mg/kg of Mycophenolate Mofetil was injected by i.p. route to different groups of animals at six different c...
متن کاملMycophenolate mofetil alters the antioxidant status in duodenum of rats: Implication for silymarin usage in mycophenolate mofetil-induced gastrointestinal disorders
Mycophenolate mofetil (MMF) as an immunosuppressive agent is used to prevent graft rejection. One of the adverse effects of long time administration of MMF is the gastrointestinal disorder. This study aimed to investigate the gastroprotective effect of silymarin (SMN) on MMF-induced gastrointestinal (GI) disorders. Twenty-four adult female Wistar rats were assigned into three groups including t...
متن کاملSilymarin attenuates mycophenolate mofetil-induced duodenal disorders in rats
Objective: The protective effect of silymarin (SMN) on mycophenolate mofetil (MMF)–induced duodenal disorders was investigated. Materials and Methods: Forty-two Wistar rats were assigned to seven groups including control and test groups. The control animals received saline and the test animals were treated with MMF (30 mg/kg, orally) and saline, MMF and SMN (25, 50, and 100 mg/kg, orally), MMF ...
متن کاملCircadian variation of gentamicin toxicity in rats.
OBJECTIVES/HYPOTHESIS Two undesired effects of the aminoglycoside antibiotic gentamicin are ototoxicity and nephrotoxicity. This study investigated if these adverse effects vary according to the circadian time of its administration. STUDY DESIGN This study entails laboratory animal research. METHODS Four groups of Sprague-Dawley rats were synchronized to a 12:12 light/dark schedule. Each gr...
متن کاملmycophenolate mofetil alters the antioxidant status in duodenum of rats: implication for silymarin usage in mycophenolate mofetil-induced gastrointestinal disorders
mycophenolate mofetil (mmf) as an immunosuppressive agent is used to prevent graft rejection. one of the adverse effects of long time administration of mmf is the gastrointestinal disorder. this study aimed to investigate the gastroprotective effect of silymarin (smn) on mmf-induced gastrointestinal (gi) disorders. twenty-four adult female wistar rats were assigned into three groups including t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Applied Biomedicine
سال: 2013
ISSN: 1214-021X,1214-0287
DOI: 10.2478/v10136-012-0024-9